| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-(1-methylethyl)- | [CAS]
301297-45-0 | [Synonyms]
SJ3991
SJ-3991
IQP0528
IQP-0528
IQP 0528
Ainuovirine Impurity 2
2,4(1H,3H)-Pyrimidinedione, 1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-(1-methylethyl)- | [Molecular Formula]
C20H24N2O3 | [MDL Number]
MFCD28502141 | [MOL File]
301297-45-0.mol | [Molecular Weight]
340.42 |
| Hazard Information | Back Directory | [Uses]
IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM[1]. | [IC 50]
HIV-1; HIV-2 | [References]
[1] Su JT, et al. A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates. Pharm Res. 2017;34(10):2163-2171. DOI:10.1007/s11095-017-2224-1 |
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