| Identification | Back Directory | [Name]
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione | [CAS]
301298-87-3 | [Synonyms]
ZIM
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3a,4,7,7a-tetrahydro- | [Molecular Formula]
C20H19N3O3 | [MOL File]
301298-87-3.mol | [Molecular Weight]
349.38 |
| Chemical Properties | Back Directory | [Boiling point ]
484.5±55.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.40±0.65(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research[1]. | [in vivo]
ZIM (i.p., 12, 24 and 48 mg/kg) can effectively reduce the frequency of chromosome micronucleus at all doses at 24 and 72 h in adult male Swiss mice, and has certain chemoprophylaxis effect, and the percentage of damage reduction ranges from 38.36 to 83.26%[1].
ZIM (i.p., 12, 24 and 48 mg/kg) reduces the frequency of cisplatin-CIS and doxorubicin-DOX-induced liver and kidney cell death. At 12, 24 and 48 mg/kg dosages, the percentage of liver damage reduction in CIS group are 79.27, 75.20 and 52.84%, and that in DOX group are 62.06, 59.44 and 77.80%, respectively. The reduction percentages of kidney injury in CIS group are 45.29, 36.09 and 41.61%, and those in DOX group are 28.00, 21.41 and 30.82%, respectively[1].
| [References]
[1] Rodrigo Juliano Oliveira, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2022 Dec 22. DOI:10.1021/acs.chemrestox.2c00275 |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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