| Identification | Back Directory | [Name]
N-(3-chloro-4-hydroxy-1-naphthyl)-4-methoxybenzenesulfonamide | [CAS]
301313-42-8 | [Synonyms]
Sirt1/2-IN-3
N-(3-chloro-4-hydroxy-1-naphthyl)-4-methoxybenzenesulfonamide
Benzenesulfonamide, N-(3-chloro-4-hydroxy-1-naphthalenyl)-4-methoxy- | [Molecular Formula]
C17H14ClNO4S | [MOL File]
301313-42-8.mol | [Molecular Weight]
363.815 |
| Hazard Information | Back Directory | [Uses]
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC50s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1]. | [References]
[1] Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. DOI:10.1021/acs.jcim.3c00556 |
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| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
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