| Identification | Back Directory | [Name]
2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[3-[(30-chloro-2-oxo-6,9,12,15,18,21,24-heptaoxa-3-azatriacont-1-yl)oxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [CAS]
3016307-75-5 | [Synonyms]
2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[3-[(30-chloro-2-oxo-6,9,12,15,18,21,24-heptaoxa-3-azatriacont-1-yl)oxy]phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [Molecular Formula]
C58H87ClN2O17 | [MOL File]
3016307-75-5.mol | [Molecular Weight]
1119.77 |
| Chemical Properties | Back Directory | [Boiling point ]
1055.9±65.0 °C(predicted) | [density ]
1.156±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Oil | [pka]
13.99±0.46(predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and Tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases[1][2]. | [References]
[1] Chen PH, et al. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS Chem. Biol. 2021 Nov 15.
[2] Hu Z, et al. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality. J Am Chem Soc. 2023 Feb 8. DOI:10.1021/jacs.2c11706 |
|
|