| Hazard Information | Back Directory | [Uses]
EGFR-IN-109 (compound 4) is an EGFR inhibitor, with the IC50 values of 25.8 and 182.3?nM for EGFRWT and EGFRT790M, respectively. EGFR-IN-109 arrests the cancer cells’ growth at the G2/M phase and induces both early and late apoptosis. EGFR-IN-109 can be used in cancer research[1]. | [IC 50]
EGFR: 25.8 nM (IC50); EGFRT790M: 182.3 nM (IC50); Caspase-3; Caspase-9; Bax; Bcl-2 | [References]
[1] Sobh EA, et al. Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket. J Biomol Struct Dyn. 2024 Mar;42(5):2369-2391. DOI:10.1080/07391102.2023.2204500 |
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