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3023438-19-6

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3023438-19-6 Structure

3023438-19-6 Structure

Identification	Back Directory
[Name] CypD-IN-4
[CAS] 3023438-19-6
[Synonyms] CypD-IN-4
[Molecular Formula] C54H63N7O11
[MOL File] 3023438-19-6.mol
[Molecular Weight] 986.12

Chemical Properties	Back Directory
[Boiling point ] 1299.6±65.0 °C(predicted)
[density ] 1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 4.06±0.10(predicted)

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[Uses] CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC50 value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].
[IC 50] Cyclophilin D: 0.057 μM (IC₅₀); Cyclophilin A: 3.4 μM (IC₅₀); Cyclophilin B: 1.1 μM (IC₅₀); Cyclophilin E: 0.8 μM (IC₅₀)
[References] [1] Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26. DOI:10.1038/s41589-022-01116-1

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