| Identification | Back Directory | [Name]
4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE | [CAS]
30235-26-8 | [Synonyms]
BUTTPARK 29\06-84
TIMTEC-BB SBB010613
IFLAB-BB F0447-0233
4-(2-pyridyl)-2-thiazolamine
4-(2-pyridyl)thiazol-2-amine
2-AMINO-4-(2-PYRIDYL)THIAZOLE
4-(2-Pyridinyl)-2-thiazolamine
4-(2-Pyridinyl)thiazol-2-amine
4-(Pyridin-2-yl)thiazol-2-amine
4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE
[4-(2-pyridyl)thiazol-2-yl]amine
2-ThiazolaMine, 4-(2-pyridinyl)-
2-Amino-4-(2-pyridyl)thiazole,97%
4-PYRIDIN-2-YL-1,3-THIAZOL-2-AMINE
4-(2-PYRIDINYL)-1,3-THIAZOL-2-AMINE
4-(2-pyridinyl)-1,3-thiazol-2-amine(SALTDATA: FREE)
4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE ISO 9001：2015 REACH | [Molecular Formula]
C8H7N3S | [MDL Number]
MFCD00460417 | [MOL File]
30235-26-8.mol | [Molecular Weight]
177.23 |
| Chemical Properties | Back Directory | [Melting point ]
173-174 °C(Solv: ethanol, 50% (64-17-5)) | [Boiling point ]
383.6±17.0 °C(Predicted) | [density ]
1.333±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
Solid | [pka]
3.40±0.10(Predicted) | [color ]
Pale brown |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-(pyridin-2-yl)thiazol-2-amine from 2-bromo-1-(2-pyridinyl)ethanone and thiourea (CAS: 17356-08-0): 2-bromo-1-(2-pyridinyl)ethanone (0.01 mol, ca. 0.76 g), thiourea (0.01 mol), and 50 mL of ethanol were added to a 100 mL round-bottomed flask, and the mixture was heated to reflux for for 4 hours. After completion of the reaction, the ethanol solvent was removed by distillation under reduced pressure. The crude product was purified by column chromatography using dichloromethane (DCM): methanol (MeOH): ammonium hydroxide (NH4OH) (20:1:0.1, v/v) as mobile phase. 4-(Pyridin-2-yl)thiazol-2-amine was finally obtained as a white solid in a yield of 1.41 g in 79.6%. | [References]
[1] Patent: CN105820163, 2016, A. Location in patent: Paragraph 0127 - 0129
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564
[3] Patent: WO2008/122787, 2008, A1. Location in patent: Page/Page column 85
[4] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[5] Journal of the Chinese Chemical Society, 2017, vol. 64, # 12, p. 1408 - 1416 |
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