| Identification | Back Directory | [Name]
Spiro[cyclopropane-1,3′-[3H]indol]-2′(1′H)-one, 6′-[2-[(3S)-3-piperidinylamino]thieno[3,2-d]pyrimidin-7-yl]- | [CAS]
3024545-83-0 | [Synonyms]
CDK7-IN-29
Spiro[cyclopropane-1,3′-[3H]indol]-2′(1′H)-one, 6′-[2-[(3S)-3-piperidinylamino]thieno[3,2-d]pyrimidin-7-yl]- | [Molecular Formula]
C21H21N5OS | [MOL File]
3024545-83-0.mol | [Molecular Weight]
391.49 |
| Hazard Information | Back Directory | [Uses]
CDK7-IN-29 (compound 20) is an inhibitor of CDK7 with an IC50 value of 1.4 nM. CDK7-IN-29 has oral activity and good pharmacokinetic (PK) properties[1]. | [IC 50]
CDK7: 1.4 nM (IC50) | [References]
[1] Hongjin Zhang, et al. Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors. Bioorg Chem. 2024 Jul:148:107456. DOI:10.1016/j.bioorg.2024.107456 |
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