| Identification | Back Directory | [Name]
2-Naphthalenol, 5-ethynyl-6-fluoro-4-[8-fluoro-4-[[(1S,2S)-2-fluorocyclopropyl]methylamino]-2-[(tetrahydro-2-methylene-1H-pyrrolizin-7a(5H)-yl)methoxy]pyrido[4,3-d]pyrimidin-7-yl]-, 2,2,2-trifluoroacetate (1:1) | [CAS]
3024991-82-7 | [Synonyms]
2-Naphthalenol, 5-ethynyl-6-fluoro-4-[8-fluoro-4-[[(1S,2S)-2-fluorocyclopropyl]methylamino]-2-[(tetrahydro-2-methylene-1H-pyrrolizin-7a(5H)-yl)methoxy]pyrido[4,3-d]pyrimidin-7-yl]-, 2,2,2-trifluoroacetate (1:1) | [Molecular Formula]
C32H28F3N5O2.C2HF3O2 | [MOL File]
3024991-82-7.mol | [Molecular Weight]
685.62 |
| Hazard Information | Back Directory | [Uses]
K-Ras-IN-3 (compound 3) is a potent GDP-KRAS G12V inhibitor with an IC50 value of 0.371 nM. K-Ras-IN-3 has the potential for the research of cancer[1]. | [IC 50]
KRas G12V: 0.371 nM (IC50) | [References]
[1] Robert B. Kargbo, et al. Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors, ACS Med. Chem. Lett. 2024, 15, 8, 1196-1198. |
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