| Chemical Properties | Back Directory | [Boiling point ]
812.5±65.0 °C(predicted) | [density ]
1.290±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.63±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 44 (Compound 26r) is an inhibitor for tubullin. Tubulin inhibitor 44 exhibits cytotoxicity in cancer cells NCI-H460, BxPC-3 and HT-29, with IC50s of 0.96, 0.66 and 0.61 nM, respectively[1]. | [References]
[1] Wang S, et al., Design, synthesis, and structure-activity relationship study of novel plinabulin derivatives as anti-tumor agents based on the co-crystal structure. Mol Divers. 2024 Apr 23. DOI:10.1007/s11030-024-10835-7 |
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