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3026416-27-0

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3026416-27-0 Structure

3026416-27-0 Structure
IdentificationBack Directory
[Name]

Dimethyl-SGD-1882
[CAS]

3026416-27-0
[Synonyms]

Dimethyl-SGD-1882
Hazard InformationBack Directory
[Uses]

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication[1].
[IC 50]

Pyrrolobenzodiazepines
[References]

[1] Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488. DOI:10.1002/anie.201510610
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