3026848-13-2

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3026848-13-2 Structure

Identification	Back Directory
[Name] Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[2,3-dihydro-3-methyl-1-(1-methyl-4-piperidinyl)-2-oxo-1H-benzimidazol-5-yl]-3-[[4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl-
[CAS] 3026848-13-2
[Synonyms] Benzamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[2,3-dihydro-3-methyl-1-(1-methyl-4-piperidinyl)-2-oxo-1H-benzimidazol-5-yl]-3-[[4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl-
[Molecular Formula] C40H55N7O3
[MOL File] 3026848-13-2.mol
[Molecular Weight] 681.91

Chemical Properties	Back Directory
[Boiling point ] 824.3±65.0 °C(predicted)
[density ] 1.23±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 11.90±0.10(predicted)

Hazard Information	Back Directory
[Uses] EZH2-IN-19 (conpound N40) is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) WT, with the IC50 of 0.32 nM. EZH2-IN-19 plays an important role in cancer research[1].
[IC 50] EZH2 WT: 0.32 nM (IC₅₀); EZH2 Y641F mutant type: 0.03 nM (IC₅₀); EZH2 Y641N: 0.08 nM (IC₅₀)
[References] [1] Di Wu, et al. Discovery of novel pyridone-benzamide derivatives possessing a 1-methyl-2-benzimidazolinone moiety as potent EZH2 inhibitors for the treatment of B-cell lymphomas. Bioorg Med Chem. 2024 May 1:105:117725. DOI:10.1016/j.bmc.2024.117725

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