| Identification | Back Directory | [Name]
pan-KRAS-IN-5 | [CAS]
3027172-23-9 | [Synonyms]
pan-KRAS-IN-5
Quinolinium, 2-[(1E)-2-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]ethenyl]-6-fluoro-1-methyl-7-[[2-(1-pyrrolidinyl)ethyl]amino]-, iodide (1:1) | [Molecular Formula]
C31H36FN4O2.I | [MOL File]
3027172-23-9.mol | [Molecular Weight]
642.55 |
| Hazard Information | Back Directory | [Uses]
pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor by targeting 5′-UTR RNA G-quadruplexes (rG4s). pan-KRAS-IN-5 induces cell cycle arrest and promptes apoptosis in KRAS-driven cancer cells[1]. | [References]
[1] Mao-Lin Li, et al. Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J Med Chem. 2024 Feb 8;67(3):1961-1981. DOI:10.1021/acs.jmedchem.3c01773 |
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