| Identification | Back Directory | [Name]
1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-5-[2-(1H-indol-3-yl)ethyl]- | [CAS]
3027413-48-2 | [Synonyms]
1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-5-[2-(1H-indol-3-yl)ethyl]- | [Molecular Formula]
C20H20N2O2 | [MOL File]
3027413-48-2.mol | [Molecular Weight]
320.39 |
| Chemical Properties | Back Directory | [Boiling point ]
530.5±50.0 °C(predicted) | [density ]
1.260±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
17.28±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
TFEB activator 3 (compound 45) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h). TFEB activator 3 plays an important role in Alzheimer’s disease (AD). TFEB activator 3 can pass blodd brain barrier[1]. | [References]
[1] Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67(11):8836-8861. DOI:10.1021/acs.jmedchem.4c00159 |
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