| Identification | Back Directory | [Name]
TCS 46B | [CAS]
302799-86-6 | [Synonyms]
TCS 46B
1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]- | [Molecular Formula]
C22H23N3O | [MDL Number]
MFCD09971137 | [MOL File]
302799-86-6.mol | [Molecular Weight]
345.44 |
| Chemical Properties | Back Directory | [Boiling point ]
440.4±38.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Powder | [pka]
11.51±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist. | [Biological Activity]
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. | [in vivo]
TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) potentiates the effects of L-DOPA in the 6-OHDA-lesioned rat[1]. | Animal Model: | Sprague?Dawley rats, 6-hydroxydopamine-lesioned (6-OHDA) rat model[1] | | Dosage: | 10 and 30 mg/kg | | Administration: | PO or IP, once | | Result: | Showed significant potentiation of the effects of L-DOPA in this model. |
| [storage]
Store at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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