| Identification | Back Directory | [Name]
HDAC8-IN-12 | [CAS]
3028095-13-5 | [Synonyms]
HDAC8-IN-12
2-Propenamide, N-hydroxy-3-[2-methoxy-4-[(1-methyl-3,6-dioxo-2-piperazinylidene)methyl]phenyl]- | [Molecular Formula]
C16H17N3O5 | [MOL File]
3028095-13-5.mol | [Molecular Weight]
331.32 |
| Hazard Information | Back Directory | [Uses]
HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer[1]. | [References]
[1] Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer |
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