| Identification | Back Directory | [Name]
2-bromo-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide | [CAS]
302939-48-6 | [Synonyms]
KL201
2-bromo-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide
Benzamide, 2-bromo-N-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)- | [Molecular Formula]
C17H14BrN3OS | [MDL Number]
MFCD01237866 | [MOL File]
302939-48-6.mol | [Molecular Weight]
388.28 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (643.87 mM) | [form ]
Solid | [color ]
White to yellow | [InChI]
1S/C17H14BrN3OS/c18-12-7-3-1-5-10(12)16(22)21-15-14-11-6-2-4-8-13(11)23-17(14)20-9-19-15/h1,3,5,7,9H,2,4,6,8H2,(H,19,20,21,22) | [InChIKey]
KFSLRFWIPVMBNT-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC=CC=C1Br)NC2=NC=NC3=C2C4=C(CCCC4)S3 |
| Hazard Information | Back Directory | [Uses]
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. | [Biological Activity]
KL201 is a circadian clock modulator th at lengthens a circadian period in cells and tissues. KL201 selectively regulate cryptochrome 1 (Cry1). It binds to FAD-binding pocket of CRY1 preventing interaction with FBXL3 and ubiquitin-dependent degradation. | [References]
[1] Simon Miller, et al. An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol. 2020 Sep 17;27(9):1192-1198.e5. DOI:10.1016/j.chembiol.2020.05.008 |
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