| Hazard Information | Back Directory | [Uses]
TLR7 agonist 20 (compound 23) is an imidazoquinoline analogue. TLR7 agonist 20 is a potent TLR7 specific agonist, with an EC50 value of 0.23 μM for hTLR7. TLR7 agonist 20 shows strong adjuvant activity on spike antibody levels which induces a strong T helper 1 (Th1) response with increase in IgG2b and IgG2c, in addition to IgG1[1]. | [IC 50]
TLR7: 0.23 μM (EC50); TLR8: 17.21 μM (EC50) | [References]
[1] Kaushik D, et al. Structure-Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist. J Med Chem. 2024 May 23;67(10):8346-8360. DOI:10.1021/acs.jmedchem.4c00464 |
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