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KRAS inhibitor-25 (compound 151a) is a pyridopyrimidine KRAS inhibitor, with an IC50 of < 100 nM against KRas G12V, KRas WT and KRas G12R[1]. | [IC 50]
KRas G12C: < 100 nM (IC50); K-Ras WT: < 100 nM (IC50); KRas G12R: < 100 nM (IC50) | [References]
[1] James Paul LAJINESS, et al. Pyridopyrimidine kras inhibitors. Patent WO 2024/040131 A1. |
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