| Hazard Information | Back Directory | [Uses]
Tpp-ce6 is a mitochondria-targeting photosensitizer formed by binding chlorophyll e6 (Ce6) to triphenylphosphine (TPP) via an ester bond. TPP-Ce6 can produce ROS under light irradiation, especially singlet oxygen, which can induce oxidative stress, leading to mitochondrial dysfunction and apoptosis. TPP-Ce6 can be used in the study of mitochondria in apoptosis and energy metabolism as well as cancer therapy[1]. | [References]
[1] Cao T G N, et al. Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood?brain barrier[J]. Acta Pharmaceutica Sinica B, 2023, 13(9): 3834-3848. DOI:10.1016/j.apsb.2023.03.023 |
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