| Identification | Back Directory | [Name]
1-Piperazinecarboxamide, N-[(4-bromophenyl)methyl]-4-[(3,5-difluorophenyl)methyl]- | [CAS]
3031789-26-8 | [Synonyms]
1-Piperazinecarboxamide, N-[(4-bromophenyl)methyl]-4-[(3,5-difluorophenyl)methyl]- | [Molecular Formula]
C19H20BrF2N3O | [MOL File]
3031789-26-8.mol | [Molecular Weight]
424.28 |
| Chemical Properties | Back Directory | [Boiling point ]
555.1±50.0 °C(predicted) | [density ]
1.451±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.28±0.20(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1]. | [References]
[1] Zhou LL, et al. Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma. Nat Commun. 2023 Nov 3;14(1):7069. DOI:10.1038/s41467-023-42784-4 |
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