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EGFR T790M/L858R-IN-7 (Compound 72) is a novel pyrimidine compound that inhibits the EGFR T790M and L858R mutation with a high efficacy (93% inhibition rate at 0.05 μM). EGFR T790M/L858R-IN-7 functions by specifically binding to the kinase domain of EGFR, thereby inhibiting its phosphorylation activity[1]. | [References]
[1] Guoqing Paul C, et al. World Intellectual Property Organization,?WO2024064091?A1 2024-03-28 |
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