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3033007-79-0

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3033007-79-0 Structure

3033007-79-0 Structure

Identification	Back Directory
[Name] PqsR-IN-3
[CAS] 3033007-79-0
[Synonyms] PqsR-IN-3
[Molecular Formula] C23H23N5O3
[MOL File] 3033007-79-0.mol
[Molecular Weight] 417.46

Chemical Properties	Back Directory
[Boiling point ] 603.1±65.0 °C(predicted)
[density ] 1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 9.73±0.40(predicted)

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[Uses] PqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441)[1].
[References] [1] Miao ZY et al. 3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa. J Med Chem. 2023 Nov 18. DOI:10.1021/acs.jmedchem.3c01328

3033007-79-0 suppliers list

Company Name:	TargetMol
Telephone:	400-821-0310 15002144251
Website:	www.targetmol.cn/

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