| Chemical Properties | Back Directory | [Boiling point ]
682.7±55.0 °C(predicted) | [density ]
1.26±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
9.58±0.10(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis[1]. | [in vivo]
PI3K/AKT-IN-1 (2000 mg/kg; p.o.; single) is non-toxic and is well tolerated by experimental animals[1]. | Animal Model: | Female rats (180-200g)[1] | | Dosage: | 2000 mg/kg | | Administration: | p.o.; single | | Result: | The median lethal dose (LD50) was greater than the test dose (2000?mg/kg). |
| [IC 50]
PI3Kγ: 6.99 μM (IC50); PI3Kδ: 4.01 μM (IC50) | [References]
[1] El-Dydamony NM, et al. Pyrimidine-5-carbonitrile based potential anticancer agents as apoptosis inducers through PI3K/AKT axis inhibition in leukaemia K562. J Enzyme Inhib Med Chem. 2022;37(1):895-911. DOI:10.1080/14756366.2022.2051022 |
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