| Chemical Properties | Back Directory | [Boiling point ]
546.620±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.198±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
2.615±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
(Neurodegenerative diseases) NDs-IN-1 (Compound 3g) inhibits the activities of key enzymes such as hBACE-1, hAChE and hMAO-B. NDs-IN-1 is a novel non-covalent multi-target inhibitor. NDs-IN-1 is mainly used in the study of neurodegenerative diseases[1]. | [IC 50]
p38 MAPK; hMAO-A; hMAO-B; hAChE; hBCHE; nNOS; iNOS; hPARP-1; PARP-2; IDO-1; RIPK1 | [References]
[1] Mousavi H et al. Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases. ACS Chem Neurosci. 2024 May 1;15(9):1828-1881. DOI:10.1021/acschemneuro.4c00055 |
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