| Identification | Back Directory | [Name]
Imidazo[1,5-a]quinoxaline-8-carboxamide, 4-amino-N-[(3S)-2,3-dihydro-6-(1,1,2,2,2-pentafluoroethyl)-3-benzofuranyl]-N-methyl- | [CAS]
3034034-32-4 | [Synonyms]
Imidazo[1,5-a]quinoxaline-8-carboxamide, 4-amino-N-[(3S)-2,3-dihydro-6-(1,1,2,2,2-pentafluoroethyl)-3-benzofuranyl]-N-methyl- | [Molecular Formula]
C22H16F5N5O2 | [MOL File]
3034034-32-4.mol | [Molecular Weight]
477.39 |
| Hazard Information | Back Directory | [Uses]
PRMT5-IN-41 (compound 130) is a potent and orally active PRMT5 inhibitor. PRMT5-IN-41 inhibits hERG ion channel with IC50 value of 1.36 μM[1]. | [in vivo]
PRMT5-IN-41 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows orally bioavailable with 77.5% and T1/2 value of 4.5, 3.34 h for IV and PO, respectively in ICR mice[1]. | [References]
[1] Bing Yao, et al. Novel prmt5 inhibitor and use thereof. WO2024067433A1. |
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