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3034182-97-0

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3034182-97-0 Structure

3034182-97-0 Structure

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[Name] PROTAC HPK1 Degrader-1
[CAS] 3034182-97-0
[Synonyms] PROTAC HPK1 Degrader-1
[Molecular Formula] C43H43N7O8
[MOL File] 3034182-97-0.mol
[Molecular Weight] 785.85

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[density ] 1.378±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 10.74±0.40(predicted)

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[Uses] PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].
[References] [1] Zeng S, et al. Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling. Bioorg Chem. 2024 Feb;143:107016. DOI:10.1016/j.bioorg.2023.107016

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