| Identification | Back Directory | [Name]
PROTAC GSPT1 degrader-1 | [CAS]
3034310-17-0 | [Synonyms]
PROTAC GSPT1 degrader-1
1H-Isoindole-1,3(2H)-dione, 5-[3-[2-[3-[3-(4-chloro-3-ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]tetrahydro-2-oxo-1(2H)-pyrimidinyl]ethyl]-1-azetidinyl]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C37H36ClN7O5 | [MOL File]
3034310-17-0.mol | [Molecular Weight]
694.18 |
| Hazard Information | Back Directory | [Uses]
PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM. (Pink: ligand for target protein (HY-W599025); Black: linker (HY-159619); Blue: ligand for E3 ligase (HY-W087383))[1] | [References]
[1] Fang Li, et al., Gspt1 degraders, compositions comprising the degrader, and methods of using the same. WO2024073871A1. |
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