| Identification | Back Directory | [Name]
Benzamide, N-[4-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl]-4-(trifluoromethyl)- | [CAS]
3034402-33-7 | [Synonyms]
Antibacterial agent 221
Benzamide, N-[4-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl]-4-(trifluoromethyl)- | [Molecular Formula]
C25H20F3N3O | [MOL File]
3034402-33-7.mol | [Molecular Weight]
435.44 |
| Chemical Properties | Back Directory | [Boiling point ]
532.7±50.0 °C(predicted) | [density ]
1.355±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.55±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
Antibacterial agent 221 (compound 3k) is a potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 221 shows significant cytotoxicity against human LO2 and HepG2 cells[1]. | [References]
[1] Song YZ, et al. Synthesis and biological evaluation of novel 1,2,3,4-tetrahydro-β-carboline derivatives as potential antibacterial agents. Bioorg Med Chem Lett. 2024 May 30:129822. DOI:10.1016/j.bmcl.2024.129822 |
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