| Chemical Properties | Back Directory | [Boiling point ]
515.020±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.490±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
-3.945±0.60(predicted) |
| Hazard Information | Back Directory | [Uses]
PF-07853578 (Example 11) is a PNPLA3 degrader with an EC50 of 8 nM. PNPLA3 degrader-1 can be used in the study of cirrhosis and hepatocellular carcinoma[1]. | [References]
[1] Christopher William Am Ende, et al. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers. WO, WO2024084360A1. 2024-04-25 |
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