| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[3-[4-[2-[9-methyl-3-(phenylmethyl)-4H,6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepin-2-yl]ethynyl]-1H-pyrazol-1-yl]-3-[2-(4-methyl-1-piperazinyl)ethyl]-1-azetidinyl]- | [CAS]
3037514-38-5 | [Synonyms]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[3-[4-[2-[9-methyl-3-(phenylmethyl)-4H,6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepin-2-yl]ethynyl]-1H-pyrazol-1-yl]-3-[2-(4-methyl-1-piperazinyl)ethyl]-1-azetidinyl]- | [Molecular Formula]
C44H44N10O5S | [MOL File]
3037514-38-5.mol | [Molecular Weight]
824.95 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.75±0.40(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BD-9136 is a potent and highly selective BRD4 PROTAC depressant. BD-9136 has low-nanomolar degradation potencies against BRD4 , and its degradation selectivity for BRD4 is 1000 times that of BRD2 and BRD3 proteins. BD-9136 has antitumor activity[1].(Pink: Desmethyl-QCA276 (HY-44103); Black: 3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol; Blue: Thalidomide-4-OH (HY-103596)) | [in vivo]
BD-9136 (20 mg/kg; Intraperitoneal injection; 5 times a week for 4 weeks) has anti-tumor effects in mouse models of tumor cell xenograft[1]. | Animal Model: | SCID mice bearing the MV4;11 xenograft tumors[1] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 5 days a week for 4 weeks | | Result: | Achieved 92% of tumor growth inhibition at the end of the treatment.
Caused no significant weight loss or other signs of toxicity in mice during the entire experiment.
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| [References]
[1] Hu J,et al. Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity. J Med Chem. 2023 Jun 22;66(12):8222-8237. DOI:10.1021/acs.jmedchem.3c00520 |
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