| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole, 1,3-bis[(4-methyl-1-piperazinyl)methyl]-9-(3-phenylpropyl)- | [CAS]
3037605-45-8 | [Synonyms]
9H-Pyrido[3,4-b]indole, 1,3-bis[(4-methyl-1-piperazinyl)methyl]-9-(3-phenylpropyl)- | [Molecular Formula]
C32H42N6 | [MOL File]
3037605-45-8.mol | [Molecular Weight]
510.72 |
| Hazard Information | Back Directory | [Uses]
Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway[1]. | [in vivo]
Antitumor agent-82 (45 mg/kg; i.p.; every two days for 16 days) shows anti-cancer activity for mouse[1]. | Animal Model: | 6-week-old male BALB/c mice[1] | | Dosage: | 45 mg/kg | | Administration: | I.p.; every two days for 16 days | | Result: | Reduced tumor volume and resulted in a considerable reduction of the tumor weight of 69.69%. |
| [References]
[1] Ao J,et al. Design, synthesis and pharmacological evaluation of β-carboline derivatives as potential antitumor agent via targeting autophagy. Eur J Med Chem. 2022 Nov 26;246:114955. DOI:10.1016/j.ejmech.2022.114955 |
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