| Identification | Back Directory | [Name]
[1]Benzopyrano[4,3-c]pyrazol-4(1H)-one, 7-methoxy-3-methyl- | [CAS]
3038756-30-5 | [Synonyms]
[1]Benzopyrano[4,3-c]pyrazol-4(1H)-one, 7-methoxy-3-methyl- | [Molecular Formula]
C12H10N2O3 | [MOL File]
3038756-30-5.mol | [Molecular Weight]
230.22 |
| Chemical Properties | Back Directory | [Boiling point ]
503.7±45.0 °C(predicted) | [density ]
1.391±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.47±0.20(predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse[1]. | [in vivo]
ATF3 inducer 1 (40 mg/kg; i.p.; three times a week for 10-weeks) shows anti-MetS (managing metabolic syndrome) activity in mouse[1]. | Animal Model: | Eight-week-old C57BL/6 male mice[1] | | Dosage: | 40 mg/kg | | Administration: | I.p.; three times a week for 10-weeks | | Result: | Decreased the bodyweight and the size of epididymal white adipose tissue (eWAT) adipocytes was notably diminished. |
| [References]
[1] Chang YH, et al. Exploration and biological evaluation of 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one as an activating transcription factor 3 inducer for managing metabolic syndrome. Eur J Med Chem. 2022 Nov 25;246:114951. DOI:10.1016/j.ejmech.2022.114951 |
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