| Identification | Back Directory | [Name]
2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE | [CAS]
303985-05-9 | [Synonyms]
BET-IN-7
2-[(2-CHLOROBENZYL)SULFANYL]-4-HYDROXY-6-PHENYL-5-PYRIMIDINECARBONITRILE
5-Pyrimidinecarbonitrile, 2-[[(2-chlorophenyl)methyl]thio]-1,6-dihydro-6-oxo-4-phenyl- | [Molecular Formula]
C18H12ClN3OS | [MDL Number]
MFCD00975818 | [MOL File]
303985-05-9.mol | [Molecular Weight]
353.83 |
| Hazard Information | Back Directory | [Uses]
BET-IN-7 (Compound 1) is a potent inhibitor of BET with a Ki and Kd of 12.27 and 89.3 μM, respectively. BET-IN-7 has the potential for the research of sepsis[1]. | [References]
[1] Chen X, et al. Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis. Eur J Med Chem. 2022 May 8;238: DOI:10.1016/j.ejmech.2022.114423 |
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Matrix Scientific
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