| Identification | Back Directory | [Name]
NLRP3-IN-44 | [CAS]
3040298-34-5 | [Synonyms]
NLRP3-IN-44
1-Piperidineethanol, 3-[[5,6,7,8-tetrahydro-4-(4-hydroxy-5-benzofuranyl)-5,8-ethanophthalazin-1-yl]amino]-, (3R)- | [Molecular Formula]
C25H30N4O3 | [MOL File]
3040298-34-5.mol | [Molecular Weight]
434.53 |
| Chemical Properties | Back Directory | [Boiling point ]
590.5±50.0 °C(predicted) | [density ]
1.325±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.52±0.50(predicted) |
| Hazard Information | Back Directory | [Uses]
NLRP3-IN-44 (compound P33) is a potent and orally active (approximately 62%) inhibitor of NLRP3, with the Kd of 17.5 nM. NLRP3-IN-44 plays an important for studying NLRP3 inflammasome-mediated diseases[1]. | [References]
[1] Zhiyuan Fu, et al. Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis. J Med Chem. 2024 Sep 12;67(17):15711-15737. DOI:10.1021/acs.jmedchem.4c01341 |
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