| Identification | Back Directory | [Name]
HuR degrader 2 | [CAS]
3040301-46-7 | [Synonyms]
HuR degrader 2
2,6-Piperidinedione, 3-[6-(1H-pyrrolo[2,3-b]pyridin-4-yl)-3-benzofuranyl]- | [Molecular Formula]
C20H15N3O3 | [MOL File]
3040301-46-7.mol | [Molecular Weight]
345.35 |
| Chemical Properties | Back Directory | [density ]
1.395±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
11.16±0.40(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon, with an HTRF ratio < 0.02[1]. | [References]
[1] Zou L, et al., Compounds for modulating hur (elavl1). WO2024114639. |
|
| Company Name: |
ChemOrigin Pharm
|
| Tel: |
15026428026 19002516454 |
| Website: |
www.chemorigin.com |
|