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3041047-51-9

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3041047-51-9 Structure

3041047-51-9 Structure

Identification	Back Directory
[Name] PF-07957472
[CAS] 3041047-51-9
[Synonyms] PF-07957472 Benzamide, 2-methyl-5-(4-methyl-1-piperazinyl)-N-[1-[2-(1-methyl-1H-pyrazol-4-yl)-4-quinolinyl]cyclopropyl]-
[Molecular Formula] C29H32N6O
[MOL File] 3041047-51-9.mol
[Molecular Weight] 480.61

Chemical Properties	Back Directory
[Boiling point ] 709.0±60.0 °C(predicted)
[density ] 1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 13.07±0.20(predicted)

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[Uses] PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model[1].
[References] [1] Garnsey MR, et al. Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model. Sci Adv. 2024 Aug 30;10(35):eado4288. DOI:10.1126/sciadv.ado4288

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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