| Identification | Back Directory | [Name]
SHP2-IN-32 | [CAS]
3043685-80-6 | [Synonyms]
SHP2-IN-32
3-Pyridinecarboxamide, N-[3-[[5-[(1S)-1-amino-1,3-dihydrospiro[2H-indene-2,4′-piperidin]-1′-yl]-2-pyrazinyl]thio]-2-chlorophenyl]-4-hydroxy- | [Molecular Formula]
C29H27ClN6O2S | [MOL File]
3043685-80-6.mol | [Molecular Weight]
559.08 |
| Hazard Information | Back Directory | [Uses]
SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC50 value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity[1]. | [References]
[1] Lv X, et al. Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors. Eur J Med Chem. 2024 Sep 5;279:116830. DOI:10.1016/j.ejmech.2024.116830 |
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