| Identification | Back Directory | [Name]
GSK-3β inhibitor 20 | [CAS]
3044109-48-7 | [Synonyms]
GSK-3β inhibitor 20
Propanamide, 2-methyl-N-[5-[3-[[(phenylamino)carbonyl]amino]phenyl]-1H-thieno[3,2-c]pyrazol-3-yl]- | [Molecular Formula]
C22H21N5O2S | [MOL File]
3044109-48-7.mol | [Molecular Weight]
419.5 |
| Chemical Properties | Back Directory | [Boiling point ]
633.4±55.0 °C(predicted) | [density ]
1.413±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.67±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC50 value?of 74.4?nM[1]. | [References]
[1] Ning Yan, et al. Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation. Bioorg Med Chem Lett. 2024 Nov 1:112:129932. DOI:10.1016/j.bmcl.2024.129932 |
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