| Identification | Back Directory | [Name]
2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide | [CAS]
304481-72-9 | [Synonyms]
PKUMDL WQ 2101
PKUMDL-WQ-2101 >=98% (HPLC)
Benzoic acid, 2,4-dihydroxy-, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide | [Molecular Formula]
C14H11N3O6 | [MDL Number]
MFCD00589939 | [MOL File]
304481-72-9.mol | [Molecular Weight]
317.25 |
| Hazard Information | Back Directory | [Uses]
PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1]. | [Biological Activity]
PKUMDL-WQ-2101 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) th at selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2101 binds to allosteric site Iwhich is located close to active site. PKUMDL-WQ-2101 inhibits tumor growth of MDA-MB-468 xenografts in mice. | [in vivo]
PKUMDL-WQ-2101 (5-20 mg/kg; i.p; daily; for 30 days) exhibits substantial inhibitory effects on MDA-MB-468 xenografts[1]. | Animal Model: | NOD.CB17 Scid/J mice injected with MDA-MB-468 cells[1] | | Dosage: | 5 mg/kg, 10 mg/kg, 20 mg/kg | | Administration: | i.p; daily; for 30 days | | Result: | Exhibited substantial inhibitory effects on MDA-MB-468 xenografts. |
| [storage]
Store at -20°C | [References]
[1] Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24(1):55-65. DOI:10.1016/j.chembiol.2016.11.013 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
|