| Identification | Back Directory | [Name]
Benzamide, 2,4,6-trichloro-N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]- | [CAS]
3046390-54-6 | [Synonyms]
Benzamide, 2,4,6-trichloro-N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]- | [Molecular Formula]
C20H22Cl3N3O3S | [MOL File]
3046390-54-6.mol | [Molecular Weight]
490.83 |
| Hazard Information | Back Directory | [Uses]
TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC50 = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice[1]. | [IC 50]
TRPV4: 0.46 μM (IC50) | [References]
[1] Wang M, et al. Exploration and structure-activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury. Bioorg Chem. 2024 Jun;147:107396. DOI:10.1016/j.bioorg.2024.107396 |
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