| Identification | Back Directory | [Name]
VEGFR-2-IN-52 | [CAS]
3046428-94-5 | [Synonyms]
VEGFR-2-IN-52
3-Thiophenecarboxamide, 4-(4-chlorophenyl)-2-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]- | [Molecular Formula]
C20H25ClN4O2S | [MOL File]
3046428-94-5.mol | [Molecular Weight]
420.96 |
| Chemical Properties | Back Directory | [Boiling point ]
552.5±50.0 °C(predicted) | [density ]
1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.51±0.46(predicted) |
| Hazard Information | Back Directory | [Uses]
VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1]. | [References]
[1] Li T, et al. Discovery of novel thiophene-3-carboxamide derivatives as potential VEGFR-2 inhibitors with anti-angiogenic properties. Bioorg Chem. 2024 Jun;147:107358. DOI:10.1016/j.bioorg.2024.107358 |
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