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3049500-54-8

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3049500-54-8 Structure

3049500-54-8 Structure

Identification	Back Directory
[Name] Antibacterial agent 229
[CAS] 3049500-54-8
[Synonyms] Antibacterial agent 229 Hydrazinecarbothioamide, 2-[2-[3-(2-amino-4-thiazolyl)-7-chloro-6-fluoro-4-oxo-1(4H)-quinolinyl]-1-methylethylidene]-
[Molecular Formula] C16H14ClFN6OS2
[MOL File] 3049500-54-8.mol
[Molecular Weight] 424.91

Chemical Properties	Back Directory
[Boiling point ] 681.5±65.0 °C(predicted)
[density ] 1.66±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 11.27±0.70(predicted)

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[Uses] Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC50 value of 10.88 μM[1].
[IC 50] TOPO IV: 10.88 μM (IC₅₀)
[References] [1] Zang ZL, et al. Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance. Eur J Med Chem. 2024 Sep 5;275:116626. DOI:10.1016/j.ejmech.2024.116626

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