| Identification | Back Directory | [Name]
Adenosine, 2'-deoxy-4'-C-ethynyl- | [CAS]
306305-07-7 | [Synonyms]
4'-Ethynyl-2'-deoxyadenosine
Adenosine, 2'-deoxy-4'-C-ethynyl-
4' Ethynyl 2' deoxyadenosine,4'Ethynyl2'deoxyadenosine | [Molecular Formula]
C12H13N5O3 | [MDL Number]
MFCD28342919 | [MOL File]
306305-07-7.mol | [Molecular Weight]
275.26 |
| Chemical Properties | Back Directory | [Boiling point ]
608.8±65.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
13.15±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1]. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
HIV-1 | [References]
[1] Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1(1):1-10. DOI:10.2174/1568005013343218 |
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