| Identification | Back Directory | [Name]
5-[(2-methylbenzyl)oxy]-2-phenyl-1-benzofuran-3-carboxylic acid | [CAS]
307552-53-0 | [Synonyms]
SLC26A3-IN-1
5-[(2-methylbenzyl)oxy]-2-phenyl-1-benzofuran-3-carboxylic acid
3-Benzofurancarboxylic acid, 5-[(2-methylphenyl)methoxy]-2-phenyl- | [Molecular Formula]
C23H18O4 | [MOL File]
307552-53-0.mol | [Molecular Weight]
358.39 |
| Hazard Information | Back Directory | [Uses]
SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1]. | [References]
[1] Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149. DOI:10.1016/j.ejmech.2023.115149 |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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