| Identification | Back Directory | [Name]
CNS 7056 | [CAS]
308242-62-8 | [Synonyms]
CS-638
CNS 7056
Vibegron
ReMiMazolaM
Remimazolan
Remimazolam Tosylate
CNS-7056;CNS7056;CNS 7056
Methyl 3-[(4S)-8-bromo-1-methyl-6-(2-pyridyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate
4H-Imidazo[1,2-a][1,4]benzodiazepine-4-propanoic acid, 8-bromo-1-methyl-6-(2-pyridinyl)-, methyl ester, (4S)-
methyl 3-[(4S)-8-bromo-1-methyl-6-pyridin-2-yl-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate CNS-7056 Remimazolam | [Molecular Formula]
C21H19BrN4O2 | [MOL File]
308242-62-8.mol | [Molecular Weight]
439.31 |
| Chemical Properties | Back Directory | [Boiling point ]
583.5±60.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.58±0.60(Predicted) | [color ]
Off-White to Pale Yellow | [InChI]
1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1 | [InChIKey]
CYHWMBVXXDIZNZ-KRWDZBQOSA-N | [SMILES]
CC1=CN=C2[C@H](CCC(OC)=O)N=C(C3=CC=CC=N3)C4=CC(Br)=CC=C4N12 |
| Hazard Information | Back Directory | [Uses]
Vibegron is a potent and selective β3 Adrenergic receptor agonist for the treatment of overactive bladder. | [Biological Activity]
Remimazolam (CNS 7056) is a benzodiazepine derivative with positive allosteric modulator (PAM) activity toward γ-aminobutyric acid type A (GABAA) receptor (pKi = 7.53/7.50/7.56 against 2.5 nM flunitrazepam for binding human/rat/yucatan micropig brain homogenates; pEC50/Emax = 6.44/375% (α1β2γ2)6.18/186% (α2β2γ2)6.04/210% (α3β2γ2)5.86/289% (α5β2γ2s) by whole cell patch clamp using cells expressing respective r at αβγ complex). Intravenous injection (25 mg/kg rats15-30 mg/kg mice) causes fast onset and short duration of sedative action with rapid recovery when compared with midazolam. |
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