| Identification | Back Directory | [Name]
LMP744 | [CAS]
308246-52-8 | [Synonyms]
LMP744
NSC-706744
5H-[1,3]Dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-
6-(3-((2-hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4,5:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione(WXG02929) | [Molecular Formula]
C24H24N2O7 | [MDL Number]
MFCD32645133 | [MOL File]
308246-52-8.mol | [Molecular Weight]
452.46 |
| Chemical Properties | Back Directory | [Melting point ]
231-234 °C | [Boiling point ]
748.1±60.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.79±0.10(Predicted) | [color ]
Brown to dark brown |
| Hazard Information | Back Directory | [Uses]
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1]. | [in vivo]
LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. | Animal Model: | Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1]. | | Dosage: | 10, 25, or 50 mg/kg/week, 4 weeks | | Administration: | I.V. push via tail vein | | Result: | Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity. |
| [IC 50]
Top1 | [storage]
Store at -20°C | [References]
[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405. DOI:10.1158/0008-5472.CAN-07-0938 |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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