| Identification | Back Directory | [Name]
Polyinosinic acid | [CAS]
30918-54-8 | [Synonyms]
Poly(rI)
Poly(IMP)
Polyinosinic acid
Poly(5’-inosinicacid)
POLY[I] POTASSIUM SALT
POLY RL POTASSIUM SALT
Polyinosinic Acid (90%)
polyinosinicacidpot.salt
Polyinosinic acid sodium
5'-Inosinic acid polymers
Polyinosinic acid (Poly I)
5’-Inosinicacid,homopolymer
Polyinosinic acid USP/EP/BP
POLYINOSINIC ACID POTASSIUM SALT
POLYINOSINIC ACID TRIPOTASSIUM SALT
POLYINOSINIC ACID (5') POTASSIUM SALT
Polyinosinic acid sodium salt，Poly I, POLY I-Na
POLYINOSINIC ACID POT. SALT, LYOPH., MR ~1200000
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)-2-oxolanyl]methyl dihydrogen phosphate | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
(C10H13N4O8P)n | [MDL Number]
MFCD00131982 | [MOL File]
30918-54-8.mol | [Molecular Weight]
348.21 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
Methanol (Slightly), Water (Sparingly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/s3 | [InChIKey]
GRSZFWQUAKGDAV-BFXIWLNFNA-N | [SMILES]
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,r| |
| Hazard Information | Back Directory | [Description]
Polyinosinic Acid ? Polycytidylic Acid, Sodium Salt, Double-Stranded is a TLR3 (Toll-like receptor 3) agonist. Known to induce interferon production. Hypochromicity: ≥40% at 248 nm. Extinction coefficient = 5000 M-1cm-1 at 260 nm, pH 7.0. Agent for generation of stable, mature dendritic cells (DC) and immunostimulant. | [Chemical Properties]
White or off-white powder, soluble in water, insoluble in organic solvents such as ethanol and acetaminophen. | [Uses]
Polyinosinic Acid is an oligolysines used in nucleic acid binding and other biomedical applications. | [Application]
Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) ? Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) ? Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand. | [benefits]
Polyinosinic acid has antiviral, anti-tumor, lymphocyte immune function enhancement and nucleic acid metabolism inhibition effects.
| [Physiological effects]
Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF.
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