| Identification | Back Directory | [Name]
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile | [CAS]
309735-96-4 | [Synonyms]
Usp22i-S02
USP22-IN-1
11-anilino-7,8,9,10-tetrahydrobenzimidazo[1,2-b]isoquinoline-6-carbonitrile
Benzimidazo[1,2-b]isoquinoline-6-carbonitrile, 7,8,9,10-tetrahydro-11-(phenylamino)-
11-(Phenylamino)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile | [Molecular Formula]
C22H18N4 | [MOL File]
309735-96-4.mol | [Molecular Weight]
338.41 |
| Chemical Properties | Back Directory | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
5.77±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
Cell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) th at exhibits anticancer activity.
Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog th at is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. |
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| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|