| Identification | Back Directory | [Name]
6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide | [CAS]
309913-42-6 | [Synonyms]
SX 011
6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
1H-Indole-3-acetamide, 6-chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl]-N,N,1-trimethyl-α-oxo- | [Molecular Formula]
C26H27ClFN3O3 | [MDL Number]
MFCD18086881 | [MOL File]
309913-42-6.mol | [Molecular Weight]
483.96 |
| Hazard Information | Back Directory | [Uses]
SX 011 is a p38 MAP kinase inhibitor. | [in vivo]
SX-011 is orally bioavailable in preclinical species (rat, 24%; monkey, 29%; dog, 43%) and has demonstrated efficacy in both acute and chronic models of inflammation in rats. Rat t1/2 = 30 min[1][2]. | [IC 50]
p38α: 9 nM (IC50); p38β: 90 nM (IC50); p38δ: > 300,000 nM (IC50); p38γ: > 300,000 nM (IC50); JNK2: 100 nM (IC50); JNK1: > 300,000 nM (IC50) |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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